NF-κB participates in mouse hair cycle control and plays distinct roles in the various pelage hair follicle types

Krieger, K.; Millar, S.E.; Mikuda, N.; Krahn, I.; Kloepper, J.E.; Bertolini, M.; Scheidereit, C.; Paus, R.; Schmidt-Ullrich, R.

NF-κB participates in mouse hair cycle control and plays distinct roles in the various pelage hair follicle types

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Item Type:	Article
Title:	NF-κB participates in mouse hair cycle control and plays distinct roles in the various pelage hair follicle types
Creators Name:	Krieger, K., Millar, S.E., Mikuda, N., Krahn, I., Kloepper, J.E., Bertolini, M., Scheidereit, C., Paus, R. and Schmidt-Ullrich, R.
Abstract:	The transcription factor NF-κB controls key features of hair follicle (HF) development, but the role of NF-κB in adult HF cycle regulation remains obscure. Using NF-κB reporter mouse models, strong NF-κB activity was detected in the secondary hair germ (SHG) of late telogen and early anagen HFs, suggesting a potential role for NF-κB in HF stem/progenitor cell activation during anagen induction. At mid-anagen, NF-κB activity was observed in the inner root sheath (IRS) and unilaterally clustered in the HF matrix, which indicates that NF-κB activity is also involved in hair fiber morphogenesis during HF cycling. A mouse model with inducible NF-κB suppression in the epithelium revealed pelage hair-type-dependent functions of NF-κB in cycling HFs. NF-κB participates in telogen-anagen transition in awl and zigzag HFs, and is required for zigzag hair bending and guard HF cycling. Interestingly, zigzag hair shaft bending depends on non-canonical NF-κB signaling, which previously has only been associated with lymphoid cell biology. Furthermore, loss of guard HF cycling suggests that in this particular hair type NF-κB is indispensable for stem cell activation, maintenance and/or growth.
Keywords:	Animal, Models, Gene Expression Regulation, Hair Follicle, Morphogenesis, NF-kappa B, Signal Transduction, Stem Cells, Transgenic, Mice, Animals, Mice
Source:	Journal of Investigative Dermatology
ISSN:	0022-202X
Publisher:	Elsevier
Volume:	138
Number:	2
Page Range:	256-264
Date:	February 2018
Additional Information:	Erratum in: J Invest Dermatol 138(9): 2084 / Copyright © 2017 The Authors. Published by Elsevier, Inc. on behalf of the Society for lnvestigative Dermatology. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Official Publication:	https://doi.org/10.1016/j.jid.2017.08.042
PubMed:	View item in PubMed

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