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| Item Type: | Article |
|---|---|
| Title: | NF-κB activation protects oligodendrocytes against inflammation |
| Creators Name: | Stone, S., Jamison, S., Yue, Y., Durose, W., Schmidt-Ullrich, R. and Lin, W. |
| Abstract: | NF-κB is a key player in inflammatory diseases, including multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). However, the effects of NF-κB activation on oligodendrocytes in MS and EAE remain unknown. We generated a mouse model that expresses IκBαΔN, a super-suppressor of NF-κB, specifically in oligodendrocytes and demonstrated that IκBαΔN expression had no effect on oligodendrocytes under normal conditions (both sexes). Interestingly, we showed that oligodendrocyte-specific expression of IκBαΔN blocked NF-κB activation in oligodendrocytes and resulted in exacerbated oligodendrocyte death and hypomyelination in young, developing mice that ectopically express IFN-γ in the CNS (both sexes). We also showed that NF-κB inactivation in oligodendrocytes aggravated IFN-γ-induced remyelinating oligodendrocyte death and remyelination failure in the cuprizone model (male mice). Moreover, we found that NF-κB inactivation in oligodendrocytes increased the susceptibility of mice to EAE (female mice). These findings imply the cytoprotective effects of NF-κB activation on oligodendrocytes in MS and EAE. |
| Keywords: | EAE, IFN-γ, Multiple Sclerosis, Myelin, NF-κB, Oligodendrocyte, Animals, Mice |
| Source: | Journal of Neuroscience |
| ISSN: | 0270-6474 |
| Publisher: | Society for Neuroscience |
| Volume: | 37 |
| Number: | 38 |
| Page Range: | 9332-9344 |
| Date: | 20 September 2017 |
| Additional Information: | Copyright © 2017 the authors |
| Official Publication: | https://doi.org/10.1523/JNEUROSCI.1608-17.2017 |
| External Fulltext: | View full text on PubMed Central |
| PubMed: | View item in PubMed |
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