ANCA-associated vasculitis and the mechanisms of tissue injury

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Item Type:	Book Section
Title:	ANCA-associated vasculitis and the mechanisms of tissue injury
Creators Name:	Schreiber, A. and Choi, M.
Abstract:	ANCA associated vasculitides (AAVs) comprise four different disease entities: I) granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis), II) microscopic polyangiitis (MPA), III) eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss syndrome), and IV) renal-limited vasculitis or isolated pauci-immune necrotizing and crescentic glomerulonephritis (NCGN). Experimental data support the notion that ANCA-induced activation of both neutrophils and monocytes is one of the main pathogenic mechanisms involved in disease induction. Binding of ANCA IgG to surface expressed ANCA antigens on myeloid cells leads to generation of reactive oxygen species (ROS), degranulation and activation of proteases, and formation of neutrophil extracellular traps (NET). Finally, activation of the complement system in AAVs by ANCA stimulated neutrophils leads to generation of C5a, which plays an important role in an amplifying inflammatory loop.
Title of Book:	Systemic Vasculitides: Current Status and Perspectives
ISBN:	978-3-319-40134-8
Publisher:	Springer
Page Range:	141-158
Number of Pages:	438
Date:	14 October 2016
Official Publication:	https://doi.org/10.1007/978-3-319-40136-2_13

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