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| Item Type: | Article |
|---|---|
| Title: | Cognitive reserve and the risk of postoperative cognitive dysfunction: a systematic review and meta-analysis |
| Creators Name: | Feinkohl, I., Winterer, G., Spies, C.D. and Pischon, T. |
| Abstract: | Background: Post-operative cognitive dysfunction (POCD) occurs in 10 to 54% of older patients during the first few weeks after surgery, but little is known about risk factors predisposing to POCD. Methods: Systematic literature review and meta-analysis of cognitive reserve indicators and POCD risk. Results: Fifteen studies on 5104 patients were included. Follow-up periods spanned 1 day to 6 months. Educational level was the most commonly assessed cognitive reserve indicator, and a longer time spent in education was associated with a reduced risk of POCD (relative risk [RR] per year increment 0.90; 95% confidence interval: [0.87; 0.94]), i.e. each year increase in education was associated with a 10% reduced risk. Similar findings were made for some analyses on education as a categorical predictor (high school versus further/higher education, RR 1.71, [1.30; 2.25]; lower than high school versus further/higher education, RR 1.69, [1.17; 2.44]) though risk was equivalent for patients with high school education and those with lower than high school education (RR 1.02; [0.78; 1.32]). Conclusion: Patients with a relatively higher level of education are at reduced risk of POCD. Risk stratification of surgical patients according to educational level may prove useful. |
| Keywords: | Cognitive Dysfunction, Cognitive Reserve, Delirium, Neuropsychological Tests, Postoperative Complications |
| Source: | Deutsches Aerzteblatt International |
| ISSN: | 1866-0452 |
| Publisher: | Deutscher Ärzte-Verlag |
| Volume: | 114 |
| Number: | 7 |
| Page Range: | 110-107 |
| Date: | 17 February 2017 |
| Additional Information: | Author's reply in: Dtsch Arztebl Int 114(20): 362. |
| Official Publication: | https://doi.org/10.3238/arztebl.2017.0110 |
| External Fulltext: | View full text on PubMed Central |
| PubMed: | View item in PubMed |
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