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Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis

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Item Type:Review
Title:Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis
Creators Name:Canete, A., Cano, E., Munoz-Chapuli, R. and Carmona, R.
Abstract:Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Childhood Vitamin A deficiency can cause xerophthalmia, lower resistance to infection and increased risk of mortality. RA signaling appears to be essential for expression of genes involved in developmental hematopoiesis, regulating the endothelial/blood cells balance in the yolk sac, promoting the hemogenic program in the aorta-gonad-mesonephros area and stimulating eryrthropoiesis in fetal liver by activating the expression of erythropoietin. In adults, RA signaling regulates differentiation of granulocytes and enhances erythropoiesis. Vitamin A may facilitate iron absorption and metabolism to prevent anemia and plays a key role in mucosal immune responses, modulating the function of regulatory T cells. Furthermore, defective RA/RAR{alpha} signaling is involved in the pathogenesis of acute promyelocytic leukemia due to a failure in differentiation of promyelocytes. This review focuses on the different roles played by vitamin A/RA signaling in physiological and pathological mouse hematopoiesis duddurring both, embryonic and adult life, and the consequences of vitamin A deficiency for the blood system.
Keywords:Vitamin A, Retinoic Acid, Hematopoiesis, Embryos, Leukemia, Vitamin A Deficiency, Animals
Source:Nutrients
ISSN:2072-6643
Publisher:MDPI
Volume:9
Number:2
Page Range:159
Date:20 February 2017
Official Publication:https://doi.org/10.3390/nu9020159
PubMed:View item in PubMed

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