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| Item Type: | Article |
|---|---|
| Title: | Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders |
| Creators Name: | Hadar, R., Edemann-Callesen, H., Reinel, C., Wieske, F., Voget, M., Popova, E., Sohr, R., Avchalumov, Y., Priller, J., van Riesen, C., Puls, I., Bader, M. and Winter, C. |
| Abstract: | The dopamine transporter (DAT) plays a pivotal role in maintaining optimal dopamine signaling. DAT-overactivity has been linked to various neuropsychiatric disorders yet so far the direct pathological consequences of it has not been fully assessed. We here generated a transgenic rat model that via pronuclear microinjection overexpresses the DAT gene. Our results demonstrate that DAT-overexpression induces multiple neurobiological effects that exceeded the expected alterations in the corticostriatal dopamine system. Furthermore, transgenic rats specifically exhibited behavioral and pharmaco-therapeutic profiles phenotypic of repetitive disorders. Together our findings suggest that the DAT rat model will constitute a valuable tool for further investigations into the pathological influence of DAT overexpression on neural systems relevant to neuropsychiatric disorders. |
| Keywords: | Animal Disease Models, Dopamine Plasma Membrane Transport Proteins, Microinjections, Nervous System Diseases, Transgenic Rats, Up-Regulation, Animals, Mice, Rats |
| Source: | Scientific Reports |
| ISSN: | 2045-2322 |
| Publisher: | Nature Publishing Group |
| Volume: | 6 |
| Page Range: | 39145 |
| Date: | 15 December 2016 |
| Official Publication: | https://doi.org/10.1038/srep39145 |
| PubMed: | View item in PubMed |
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