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| Item Type: | Article |
|---|---|
| Title: | Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1 |
| Creators Name: | Martino, D.J., Ashley, S., Koplin, J., Ellis, J., Saffery, R., Dharmage, S.C., Gurrin, L., Matheson, M.C., Kalb, B., Marenholz, I., Beyer, K., Lee, Y.A., Hong, X., Wang, X., Vukevic, D., Motyer, A., Leslie, S., Allen, K.J. and Ferreira, M.A.R. |
| Abstract: | BACKGROUND: Genetic variants for IgE-mediated peanut allergy are yet to be fully characterized and to date only one genomewide association study (GWAS) has been published. OBJECTIVE: To identify genetic variants associated with challenge-proven peanut allergy. METHODS: We carried out a GWAS comparing 73 infants with challenge-proven IgE-mediated peanut allergy against 148 non-allergic infants (all ~ 1 year old). We tested a total of 3.8 million single nucleotide polymorphisms, as well as imputed HLA alleles and amino acids. Replication was assessed by de novo genotyping in a panel of additional 117 cases and 380 controls, and in silico testing in two independent GWAS cohorts. RESULTS: We identified 21 independent associations at P </= 5 x 10-5 but were unable to replicate these. The most significant HLA association was the previously reported amino acid variant located at position 71, within the peptide-binding groove of HLA-DRB1 (P = 2 x 10-4 ). Our study therefore reproduced previous findings for the association between peanut allergy and HLA-DRB1 in this Australian population. CONCLUSIONS AND CLINICAL RELEVANCE: Genetic determinants for challenge-proven peanut allergy include alleles at the HLA-DRB1 locus. |
| Keywords: | Food Allergy, Genetics, GWAS, Hypersensitivity, Peanut Allergy |
| Source: | Clinical and Experimental Allergy |
| ISSN: | 0954-7894 |
| Publisher: | Wiley-Blackwell |
| Volume: | 47 |
| Number: | 2 |
| Page Range: | 217-223 |
| Date: | February 2017 |
| Additional Information: | Copyright © 2016 John Wiley & Sons Ltd |
| Official Publication: | https://doi.org/10.1111/cea.12863 |
| PubMed: | View item in PubMed |
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