Polycomb and lung cancer: when the dosage makes the (kind of) poison

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Item Type:	Article
Title:	Polycomb and lung cancer: when the dosage makes the (kind of) poison
Creators Name:	Gargiulo, G., Citterio, E. and Serresi, M.
Abstract:	The Polycomb transcriptional repressors regulate normal tissue homeostasis and their function is often hijacked during oncogenesis. We recently uncovered the Polycomb repressive complex-2 (PRC2) genes Ezh2 and Eed as oncogenotype-dependent cancer genes. Notably, within the same oncogenotype, PRC2 dosage modulates lung tumor homeostasis and critically impacts non-tumor tissue function.
Keywords:	Epigenetics, Ezh2, Inflammation, Kras, Lung Cancer, p53, Polycomb
Source:	Molecular & Cellular Oncology
ISSN:	2372-3556
Publisher:	Taylor & Francis
Volume:	3
Number:	3
Page Range:	e1152345
Date:	May 2016
Official Publication:	https://doi.org/10.1080/23723556.2016.1152345
PubMed:	View item in PubMed

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