Item Type: | Article |
---|---|
Title: | Polycomb and lung cancer: when the dosage makes the (kind of) poison |
Creators Name: | Gargiulo, G., Citterio, E. and Serresi, M. |
Abstract: | The Polycomb transcriptional repressors regulate normal tissue homeostasis and their function is often hijacked during oncogenesis. We recently uncovered the Polycomb repressive complex-2 (PRC2) genes Ezh2 and Eed as oncogenotype-dependent cancer genes. Notably, within the same oncogenotype, PRC2 dosage modulates lung tumor homeostasis and critically impacts non-tumor tissue function. |
Keywords: | Epigenetics, Ezh2, Inflammation, Kras, Lung Cancer, p53, Polycomb |
Source: | Molecular & Cellular Oncology |
ISSN: | 2372-3556 |
Publisher: | Taylor & Francis |
Volume: | 3 |
Number: | 3 |
Page Range: | e1152345 |
Date: | May 2016 |
Official Publication: | https://doi.org/10.1080/23723556.2016.1152345 |
PubMed: | View item in PubMed |
Repository Staff Only: item control page