TAK1 adaptor proteins TAB2 and TAB3 link the signalosome to B cell receptor-induced IKK activation

Tools

Item Type:	Article
Title:	TAK1 adaptor proteins TAB2 and TAB3 link the signalosome to B cell receptor-induced IKK activation
Creators Name:	Shinohara, H., Yasuda, T. and Kurosaki, T.
Abstract:	Transforming growth factor-{beta}-activated kinase (TAK)1-binding proteins (TAB) activate nuclear factor-{kappa}B by linking TAK1 to signaling molecules. We investigated the mechanisms underlying B cell receptor (BCR) signaling in TAB2- and TAB3-deficient and TAB3 domain deletion mutant DT40 B cell lines. Loss of TAB2 or TAB3 abolished BCR-induced inhibitor of {kappa}B kinase (IKK) activation and TAK1 binding to caspase recruitment domain membrane-associated guanylate kinase protein (CARMA)1. Deletion of TAB3, coupling of ubiquitin conjugation to ER degradation, coiled-coil, and zinc finger domains blocked IKK activation and association with CARMA1. Thus, TAB2 and TAB3 connect signaling molecules that activate IKK in BCR signaling.
Keywords:	BCR Signaling, TAK1, TAB, IKK, DT40 B Cells, Gene Targeting, Animals, Chickens
Source:	FEBS Letters
ISSN:	0014-5793
Publisher:	Wiley-Blackwell
Volume:	590
Number:	18
Page Range:	3264-3269
Date:	September 2016
Official Publication:	https://doi.org/10.1002/1873-3468.12342
PubMed:	View item in PubMed

Repository Staff Only: item control page