Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner

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Item Type:	Article
Title:	Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner
Creators Name:	Xu, X., Meng, Q., Erben, U., Wang, P., Glauben, R., Kuehl, A.A., Wu, H., Ma, C.W., Hu, M., Wang, Y., Sun, W., Jia, J., Wu, X., Chen, W., Siegmund, B. and Qin, Z.
Abstract:	Myeloid-derived suppressor cells (MDSCs) are well known for their capacity to suppress antitumor T-cell responses, but their effects on B-cell function and antibody production remain unclear. Here, we found that MDSCs that accumulated around the germinal center in the spleen of tumor-bearing mice co-located with B cells. In the presence of MDSCs, the antibody reaction to a surrogate antigen was significantly enhanced in mice, especially the immunoglobulin (Ig)A subtype. Co-culture with MDSCs promoted both proliferation and differentiation of B cells into IgA-producing plasma cells in vitro. Interestingly, the cross talk between MDSCs and B cells required cell-cell contact. MDSCs from tumor necrosis factor receptor (TNFR) 2(-/-) mice, but not from TNFR1(-/-) mice, failed to promote B-cell responses. Further investigation suggested that interleukin-10 and transforming growth factor-{beta}1 were crucial for the MDSC-mediated promotion of IgA responses. These results demonstrate a novel mechanism of MDSC-mediated immune regulation during tumor growth.
Keywords:	B Cells, IgA, MDSCs, TNFR2, Animals, Mice
Source:	Cellular and Molecular Immunology
ISSN:	1672-7681
Publisher:	Chinese Society of Immunology
Volume:	14
Number:	7
Page Range:	597-606
Date:	July 2017
Official Publication:	https://doi.org/10.1038/cmi.2015.103
PubMed:	View item in PubMed

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