Orchestrating Wnt signalling for metabolic liver zonation

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Item Type:	Editorial
Title:	Orchestrating Wnt signalling for metabolic liver zonation
Creators Name:	Birchmeier, W.
Abstract:	Wnt/{beta}-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/{beta}-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanisms that influence organ development and regeneration.
Keywords:	Liver, Signal Transduction, Wnt Proteins, Beta Catenin
Source:	Nature Cell Biology
ISSN:	1465-7392
Publisher:	Nature Publishing Group
Volume:	18
Number:	5
Page Range:	463-465
Date:	May 2016
Official Publication:	https://doi.org/10.1038/ncb3349
PubMed:	View item in PubMed

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