Elementary immunology: Na(+) as a regulator of immunity

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Item Type:	Review
Title:	Elementary immunology: Na(+) as a regulator of immunity
Creators Name:	Schatz, V., Neubert, P., Schröder, A., Binger, K., Gebhard, M., Müller, D.N., Luft, F.C., Titze, J. and Jantsch, J.
Abstract:	The skin can serve as an interstitial Na(+) reservoir. Local tissue Na(+) accumulation increases with age, inflammation and infection. This increased local Na(+) availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na(+) availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na(+) levels bears broad therapeutic potential: increasing local Na(+) availability may help in treating infections, while lowering tissue Na(+) levels may be used to treat, for example, autoimmune and cardiovascular diseases.
Keywords:	Local Na+ Availability, Skin Salt Storage, Macrophages, T Cells, Immune Cell Functions And Activation, Animals, Mice
Source:	Pediatric Nephrology
ISSN:	0931-041X
Publisher:	Springer
Volume:	32
Number:	2
Page Range:	201-210
Date:	February 2017
Official Publication:	https://doi.org/10.1007/s00467-016-3349-x
PubMed:	View item in PubMed

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