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| Item Type: | Article |
|---|---|
| Title: | Obesity and post-operative cognitive dysfunction: a systematic review and meta-analysis |
| Creators Name: | Feinkohl, I., Winterer, G. and Pischon, T. |
| Abstract: | Background: Post-operative cognitive dysfunction (POCD) occurs frequently after surgery, and is related to dementia and premature death. Obesity increases the risk of late-life cognitive impairment, but little is known about its role in POCD. We conducted a systematic review and meta-analysis of studies on the association between obesity and risk of POCD. Methods: PubMed and the Cochrane Library were systematically searched. Studies were included if they had prospective designs, reported on human adults undergoing surgery, if cognitive function was measured pre- and post-surgery, if obesity, body mass index (BMI) and/or body weight were ascertained, and if associations with POCD were reported as relative risks or odds ratios. Underweight, weight loss, and post-operative delirium were not considered. Results: Inclusion criteria were met by six articles. Samples totaled 1432 older patients (mean age ≥62 years) who were followed up for 24 hours to twelve months after surgery. Analysis of studies with obesity defined as a categorical measure found a non-significantly higher risk of POCD among persons with BMI > 30 kg/m2 versus ≤30 kg/m2 (RR 1.27; 95% CI 0.95, 1.70; p = 0.10). No such associations were found for studies that analyzed BMI or body weight continuously as predictors of POCD (RR 0.98 per kg/m2; 95% CI 0.93, 1.03, p = 0.45; RR 0.99 per kg; 95% CI 0.89, 1.09; p = 0.83, respectively). Conclusions: Few studies have addressed the topic, and the results of these studies provide only limited support for an increased risk of POCD in patients who are obese. Further large-scale, prospective investigations are necessary for clarification. |
| Keywords: | Obesity, Body Weight, Adiposity, Post-Operative Cognitive Dysfunction, POCD |
| Source: | Diabetes/Metabolism Research and Reviews |
| ISSN: | 1520-7560 |
| Publisher: | Wiley-Blackwell |
| Volume: | 32 |
| Number: | 6 |
| Page Range: | 643-651 |
| Date: | September 2016 |
| Official Publication: | https://doi.org/10.1002/dmrr.2786 |
| PubMed: | View item in PubMed |
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