Enhancing repair of the mammalian heart

Tools

Item Type:	Article
Title:	Enhancing repair of the mammalian heart
Creators Name:	Santini, M.P., Tsao, L., Monassier, L., Theodoropoulos, C., Carter, J., Lara-Pezzi, E., Slonimsky, E., Salimova, E., Delafontain, P., Song, Y.H., Bergmann, M., Freund, C., Suzuki, K. and Rosenthal, N.
Abstract:	The injured mammalian heart is particularly susceptible to tissue deterioration, scarring, and loss of contractile function in response to trauma or sustained disease. We tested the ability of a locally acting insulin-like growth factor-1 isoform (mIGF-1) to recover heart functionality, expressing the transgene in the mouse myocardium to exclude endocrine effects on other tissues. supplemental mIGF-1 expression did not perturb normal cardiac growth and physiology. Restoration of cardiac function in post-infarct mIGF-1 transgenic mice was facilitated by modulation of the inflammatory response and increased antiapoptotic signaling. mIGF-1 ventricular tissue exhibited increased proliferative activity several weeks after injury. The canonical signaling pathway involving Akt, mTOR, and p70S6 kinase was not induced in mIGF-1 hearts, which instead activated alternate PDK1 and SGK1 signaling intermediates. The robust response achieved with the mIGF-1 isoform provides a mechanistic basis for clinically feasible therapeutic strategies for improving the outcome of heart disease.
Keywords:	Cardiac Muscle, Insulin-Like Growth Factor-1, Regeneration, Wound Healing, Animals, Mice
Source:	Circulation Research
ISSN:	0009-7330
Publisher:	American Heart Association
Volume:	100
Number:	12
Page Range:	1732-1740
Date:	22 June 2007
Official Publication:	https://doi.org/10.1161/CIRCRESAHA.107.148791
PubMed:	View item in PubMed

Repository Staff Only: item control page