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| Item Type: | Article |
|---|---|
| Title: | Characterizing the phenotype of multiple sclerosis-associated depression in comparison with idiopathic major depression |
| Creators Name: | Hasselmann, H., Bellmann-Strobl, J., Ricken, R., Oberwahrenbrock, T., Rose, M., Otte, C., Adli, M., Paul, F., Brandt, A.U., Finke, C. and Gold, S.M. |
| Abstract: | BACKGROUND: Depression is a common co-morbidity in patients with multiple sclerosis (MS). While somatic symptoms of MS correlate with depression levels, it is unclear whether the clinical presentation of MS-associated depression differs from patients with "idiopathic" major depressive disorder (MDD). OBJECTIVE: To compare the clinical phenotype of depression among MS and idiopathic MDD patients. METHODS: Mean relative contribution of individual Beck Depression Inventory-II (BDI-II) items was evaluated among n = 139 patients with relapsing-remitting MS and n = 85 MDD patients without somatic illness. Next, comparisons were repeated in n = 38 MS with clinically relevant depressive symptoms (BDI-II > 19) and n = 38 MDD patients matched for sex, age, and depression severity. Finally, the underlying construct of depression was compared across groups using confirmatory factor analysis (CFA). RESULTS: Comparisons on a whole-group level produced the expected differences along somatic/non-somatic symptoms. However, when appropriately controlling for depression severity, age, and sex, only four items contributed differentially to BDI-II total scores in MS versus MDD. CFA suggested that the underlying depression construct is essentially identical in both groups. CONCLUSION: The clinical phenotype of "idiopathic" MDD and MS-associated depression appears similar when adequately examined. The relevance of these findings for psychotherapeutic approaches for MS-associated depression should be explored in future studies. |
| Keywords: | Depression, Multiple Sclerosis |
| Source: | Multiple Sclerosis Journal |
| ISSN: | 1352-4585 |
| Publisher: | Sage Publications |
| Volume: | 22 |
| Number: | 11 |
| Page Range: | 1476-1484 |
| Date: | October 2016 |
| Official Publication: | https://doi.org/10.1177/1352458515622826 |
| PubMed: | View item in PubMed |
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