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| Item Type: | Article |
|---|---|
| Title: | The C5a chemoattractant receptor mediates mucosal defence to infection |
| Creators Name: | Höpken, U.E., Lu, B., Gerard, N.P. and Gerard, C. |
| Abstract: | A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages. This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the complement anaphyla-toxins(1-3). The apparent redundancy of these receptors suggests that they have an important underlying role in host defence. To isolate the contribution of particular molecules, we disrupted a gene that encodes a single chemoattractant receptor. Here we show that mice deficient in the chemoattractant C5a receptor, in comparison to their wild-type littermates, were unable to clear intrapulmonary-instilled Pseudomonas aeruginosa, despite a marked increase in neutrophil influx, and succumbed to pneumonia. These C5a-receptor-deficient mice challenged with sublethal inocula of Pseudomonas become superinfected with secondary bacterial strains. We conclude that the C5a receptor has a non-redundant function, and is required for mucosal host defence in the lung. |
| Keywords: | Bacterial Pneumonia, Complement C5a, Innate Immunity, Knockout Mice, Leukocyte Chemotaxis, Lung, Mucosal Immunity, Neutrophils, Peritoneum, Phagocytosis, Pseudomonas Infections, Animals, Mice |
| Source: | Nature |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Volume: | 383 |
| Number: | 6595 |
| Page Range: | 86-89 |
| Date: | 5 September 1996 |
| Official Publication: | https://doi.org/10.1038/383086a0 |
| PubMed: | View item in PubMed |
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