![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Accepted manuscript (final draft))
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB |
| Item Type: | Review |
|---|---|
| Title: | Protein sorting gone wrong - VPS10P domain receptors in cardiovascular and metabolic diseases |
| Creators Name: | Schmidt, V. and Willnow, T.E. |
| Abstract: | VPS10P domain receptors are a unique class of sorting receptors that direct intracellular transport of target proteins in neurons and that play central roles in neurodegenerative processes. Surprisingly, genome-wide association studies now implicate the very same receptors in cardiovascular and metabolic disturbances. In this review, we discuss current findings that uncovered some of the molecular mechanisms whereby sorting receptors, such as SORLA, sortilin, and SORCS1 control homeostasis in cardiovascular and metabolic tissues, and how they promote hypercholesterolemia, atherosclerosis, obesity, and diabetes, when being altered. |
| Keywords: | Protein Sorting, VPS10P Domain Receptors, Lipoprotein Receptors, GWAS, Risk Genes, Cholesterol Metabolism, Mouse Models |
| Source: | Atherosclerosis |
| ISSN: | 0021-9150 |
| Publisher: | Elsevier |
| Volume: | 245 |
| Page Range: | 194-199 |
| Date: | February 2016 |
| Official Publication: | https://doi.org/10.1016/j.atherosclerosis.2015.11.027 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
