![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (accepted manuscript (final draft))
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
5MB |
| Item Type: | Review |
|---|---|
| Title: | The role of microglia and macrophages in glioma maintenance and progression |
| Creators Name: | Hambardzumyan, D., Gutmann, D.H. and Kettenmann, H. |
| Abstract: | There is a growing recognition that gliomas are complex tumors composed of neoplastic and non-neoplastic cells, which each individually contribute to cancer formation, progression and response to treatment. The majority of the non-neoplastic cells are tumor-associated macrophages (TAMs), either of peripheral origin or representing brain-intrinsic microglia, that create a supportive stroma for neoplastic cell expansion and invasion. TAMs are recruited to the glioma environment, have immune functions, and can release a wide array of growth factors and cytokines in response to those factors produced by cancer cells. In this manner, TAMs facilitate tumor proliferation, survival and migration. Through such iterative interactions, a unique tumor ecosystem is established, which offers new opportunities for therapeutic targeting. |
| Keywords: | Central Nervous System Neoplasms, Disease Progression, Glioma, Macrophages, Microglia, Animals |
| Source: | Nature Neuroscience |
| ISSN: | 1097-6256 |
| Publisher: | Nature Publishing Group |
| Volume: | 19 |
| Number: | 1 |
| Page Range: | 20-27 |
| Date: | January 2016 |
| Official Publication: | https://doi.org/10.1038/nn.4185 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
