Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

H2S- and NO-signaling pathways in Alzheimer's amyloid vasculopathy: synergism or antagonism?

[thumbnail of 15309oa.pdf] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB

Item Type:Review
Title:H2S- and NO-signaling pathways in Alzheimer's amyloid vasculopathy: synergism or antagonism?
Creators Name:Salmina, A.B., Komleva, Y.K., Szijártó, I.A., Gorina, Y.V., Lopatina, O.L., Gertsog, G.E., Filipovic, M.R. and Gollasch, M.
Abstract:Alzheimer's type of neurodegeneration dramatically affects H2S and NO synthesis and interactions in the brain, which results in dysregulated vasomotor function, brain tissue hypoperfusion and hypoxia, development of perivascular inflammation, promotion of Aβ deposition, and impairment of neurogenesis/angiogenesis. H2S- and NO-signaling pathways have been described to offer protection against Alzheimer's amyloid vasculopathy and neurodegeneration. This review describes recent developments of the increasing relevance of H2S and NO in Alzheimer's disease (AD). More studies are however needed to fully determine their potential use as therapeutic targets in Alzheimer's and other forms of vascular dementia.
Keywords:H2S, Vascular Dysfunction, Alzheimer Disease (AD), NO, KCNQ Channels, Obesity
Source:Frontiers in Physiology
ISSN:1664-042X
Publisher:Frontiers Media SA
Volume:6
Page Range:361
Date:11 December 2015
Official Publication:https://doi.org/10.3389/fphys.2015.00361
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library