Roles of microRNAs in B lymphocyte physiology and oncogenesis

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Item Type:	Book Section
Title:	Roles of microRNAs in B lymphocyte physiology and oncogenesis
Creators Name:	Muljo, S.A. and Rajewsky, K.
Abstract:	B cells differentiate from hematopoietic stem and progenitor cells in a programmed fashion according to instructions encoded in the genome. The central dogma of molecular biology states that DNA is transcribed into RNA, which is then translated into protein. However, we now appreciate that there are several classes of RNA that are untranslated but perform vital biological functions. The genome is decoded by the coordinated action of transcription and chromatin factors in each cell, and the resulting transcriptome or gene expression program is further regulated post-transcriptionally. This chapter will review the latter mode of control by an evolutionarily conserved microRNA-mediated gene silencing pathway, in the context of B cell biology. We discuss the discovery of this class of small regulatory RNAs and a few examples to illustrate their roles during B cell development, function, and transformation.
Keywords:	Gene Expression, Humoral Immunity, Leukemia, Lymphocyte Development, Lymphoma, MicroRNA, Post-Transcriptional Regulation
Source:	Molecular Biology of B Cells: Second Edition
Title of Book:	Molecular Biology of B Cells
ISBN:	978-0-12-397933-9
Publisher:	Academic Press
Page Range:	65-73
Date:	2015
Official Publication:	https://doi.org/10.1016/B978-0-12-397933-9.00005-9

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