Ultrahigh-field MPRAGE magnetic resonance angiography at 7.0 T in patients with cerebrovascular disease

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Item Type:	Article
Title:	Ultrahigh-field MPRAGE magnetic resonance angiography at 7.0 T in patients with cerebrovascular disease
Creators Name:	Madai, V.I., von Samson-Himmelstjerna, F.C., Sandow, N., Weiler, F., Bauer, M., Vajkoczy, P., Günther, M., Dusek, P., von Gottberg, P., Niendorf, T., Wuerfel, J. and Sobesky, J.
Abstract:	Objectives: Time-of-flight (TOF) magnetic-resonance-angiography (MRA) identifies vessel pathology in cerebrovascular disease. At 7.0 T, the clinical performance of TOF-MRA is constrained owing to radiofrequency power deposition. We studied the diagnostic value of whole-brain MPRAGE-based MRA as an alternative imaging technique in comparison to the clinical standard 3.0 T TOF-MRA. Methods: Patients with stroke and/or moya-moya disease were included. TOF-MRA was performed at 3.0 T and MPRAGE-MRA at 7.0 T. Two radiologists rated the MRAs independently for overall quality and local arterial segment visualization. The identification of steno-occlusive pathology was reported for each protocol. Results: In 18 patients (9 females; 6 patients with moya-moya) 7.0 T MPRAGE-MRA provided better overall image quality and better distinction of small structures compared to 3.0 T TOF-MRA. These findings were pronounced in the proximal segments of the anterior cerebral artery (A1), middle cerebral artery (M1, M2), posterior cerebral artery (P1) and the posterior communicating artery. Seven steno-occlusive findings were identified by both imaging protocols. Conclusions: For clinical studies using ultrahigh field MRI, 7.0 T MPRAGE-MRA provides a suitable alternative to TOF-MRA imaging to identify brain vessel pathology and yields simultaneous structural brain imaging within clinically feasible acquisition times.
Keywords:	Magnetic Resonance Imaging, 7 T MRI, Angiography, Cerebrovascular Disease, Diagnostic Imaging
Source:	European Journal of Radiology
ISSN:	0720-048X
Publisher:	Elsevier
Volume:	84
Number:	12
Page Range:	2613-2617
Date:	December 2015
Official Publication:	https://doi.org/10.1016/j.ejrad.2015.09.021
PubMed:	View item in PubMed

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