Angiotensin-(1-7) and Mas: a brief history

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Item Type:	Book Section
Title:	Angiotensin-(1-7) and Mas: a brief history
Creators Name:	Alenina, N. and dos Santos, R.A.
Abstract:	Angiotensin-(1-7) is a vasoactive peptide of the renin-angiotensin system (RAS), which is generated mainly by angiotensin-converting enzyme 2 (ACE2) and exerts its actions via activation of its receptor Mas. The Ang-(1-7)/ACE2/Mas axis is nowadays considered to be a main mechanism, which counterbalances the vasoconstrictive actions of classical RAS, which includes renin, ACE, ANG II, and its receptors AT(1) and AT(2). Whereas the classical RAS has been known for more than 100 years, the protective arm of the RAS was relatively recently discovered. Both Mas and Ang-(1-7) were first described almost 30 years ago; however, it took an additional 15 years until the interaction of these components was revealed. The third component, ACE2, was the latest to be discovered, in 2000. Interestingly, besides carboxypeptidase activity, ACE2 turned out to have totally different functions and was shown to mediate the adsorption of large amino acids in the gut and to be the receptor for the human severe acute respiratory syndrome virus. Here, we will shortly describe the story of Mas and Ang-(1-7), which was full of errors and uncertainty at the beginning, until the inter-relationship between the two was unveiled in 2003.
Keywords:	Angiotensin-(1-7), Mas, Receptor, Renin–Angiotensin System, ACE2
Source:	The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications
Title of Book:	The Protective Arm of the Renin Angiotensin System (RAS)
ISBN:	9780128013649
Publisher:	Elsevier
Page Range:	155-159
Date:	2015
Official Publication:	https://doi.org/10.1016/B978-0-12-801364-9.00021-3

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