Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis

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Item Type:	Article
Title:	Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis
Creators Name:	Pfuhl, C., Oechtering, J., Rasche, L., Gieß, R.M., Behrens, J.R., Wakonig, K., Freitag, E., Pache, F.C., Otto, C., Hofmann, J., Eberspächer, B., Bellmann-Strobl, J., Paul, F. and Ruprecht, K.
Abstract:	Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection. A characteristic feature of MS is an intrathecal synthesis of immunoglobulin (Ig)G. In 90 patients with clinically isolated syndromes/early relapsing-remitting MS, serum antibodies to Epstein-Barr nuclear antigen-1, but not to EBV viral capsid antigen, rubella, or varicella zoster virus, were higher (p=0.03) in those with than those without a calculated intrathecal IgG synthesis >0% and correlated with the percentage (r=0.27, p=0.009) and concentration (r=0.27, p=0.012) of intrathecally produced IgG. These findings suggest a link between EBV infection and the events leading to intrathecal IgG synthesis in patients with MS.
Keywords:	Multiple Sclerosis, Epstein–Barr Virus, Intrathecal Immunoglobulin G, Oligoclonal Bands, Epstein-Barr Nuclear Antigen-1, Antibodies
Source:	Journal of Neuroimmunology
ISSN:	0165-5728
Publisher:	Elsevier
Volume:	285
Page Range:	156-160
Date:	15 August 2015
Official Publication:	https://doi.org/10.1016/j.jneuroim.2015.06.012
PubMed:	View item in PubMed

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