Real-time phase contrast magnetic resonance imaging for assessment of haemodynamics: from phantom to patients

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Item Type:	Article
Title:	Real-time phase contrast magnetic resonance imaging for assessment of haemodynamics: from phantom to patients
Creators Name:	Traber, J., Wurche, L., Dieringer, M.A., Utz, W., von Knobelsdorff-Brenkenhoff, F., Greiser, A., Jin, N. and Schulz-Menger, J.
Abstract:	OBJECTIVES: Assessment of haemodynamics is crucial in many cardiac diseases. Phase contrast MRI (PC-MRI) can accurately access it. Arrhythmia is a major limitation in conventional segmented PC-MRI (SEG). A real-time PC-MRI sequence (RT) could overcome this. We validated RT by comparing to SEG. METHODS: A prototype RT using shared velocity encoding was tested against SEG at 1.5 T in a flow phantom and consecutively included patients with (n = 55) or without (n = 59) aortic valve disease. In patients with atrial fibrillation (Afib, n = 15), only RT was applied. Phantom: PC images were acquired in front of and behind an interchangeable aortic-stenosis-like inlay. Mean velocity and flow were quantified. PATIENTS: PC images were acquired in the ascending aorta, pulmonary trunk and superior caval vein. Peak velocity, stroke volume and regurgitant fraction were quantified. RESULTS: Phantom: Mean velocities (11 +/- 1 to 207 +/- 10 cm/s) and flow correlated closely between SEG and RT (r >/= 0.99, ICC >/= 0.98, p < 0.0005). Patients without AVD or with aortic regurgitation: Concordance of SEG and RT was excellent regarding peak velocities, stroke volumes (r >/= 0.91, ICC >/= 0.94, p < 0.0005) and regurgitant fractions (r = 0.95, ICC = 0.95, p < 0.0005). RT was feasible in all patients with Afib. CONCLUSIONS: The real-time sequence is accurate compared to conventional segmented PC-MRI. Its applicability in Afib was shown. Real-time PC-MRI might become a valuable tool in arrhythmia.
Keywords:	Blood Flow Velocity, Atrial Fibrillation, Magnetic Resonance Imaging, Aortic Valve Insufficiency, Phantoms, Imaging
Source:	European Radiology
ISSN:	0938-7994
Publisher:	Springer
Volume:	26
Number:	4
Page Range:	986-996
Date:	April 2016
Official Publication:	https://doi.org/10.1007/s00330-015-3897-7
PubMed:	View item in PubMed

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