Pharmacological interference with protein-protein interactions of A-kinase anchoring proteins as a strategy for the treatment of disease

Tools

Preview

Item Type:	Article
Title:	Pharmacological interference with protein-protein interactions of A-kinase anchoring proteins as a strategy for the treatment of disease
Creators Name:	Deák, V.A. and Klussmann, E.
Abstract:	A-kinase anchoring proteins (AKAPs) control the localization of cAMP-dependent protein kinase A (PKA) by tethering PKA to distinct cellular compartments. Through additional direct protein-protein interactions with PKA substrates and other signaling molecules they form multi-protein complexes. Thereby, AKAPs regulate the access of PKA to its substrates in a temporal and spatial manner as well as the local crosstalk of cAMP/PKA with other signaling pathways. Due to the increasing information on their molecular functioning and three-dimensional structures, and their emerging roles in the development of diseases, AKAPs move into the focus as potential drug targets. In particular, targeting AKAP-dependent protein-protein interactions for interference with local signal processing inside cells potentially allows for the development of therapeutics with high selectivity and fewer side effects.
Keywords:	A Kinase Anchor Proteins, Cyclic AMP-Dependent Protein Kinases, Drug Design, Molecular Targeted Therapy, Protein Conformation, Signal Transduction, Animals
Source:	Current Drug Targets
ISSN:	1389-4501
Publisher:	Bentham
Volume:	17
Number:	10
Page Range:	1147-1171
Date:	1 August 2016
Official Publication:	https://doi.org/10.2174/1389450116666150416114247
PubMed:	View item in PubMed

Repository Staff Only: item control page

Download Statistics

Downloads

Downloads per month over past year