Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Specific microRNAs regulate heat stress responses in Caenorhabditis elegans

[thumbnail of Article] PDF (Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB
[thumbnail of Supplementary Information] PDF (Supplementary Information) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
541kB

Item Type:Article
Title:Specific microRNAs regulate heat stress responses in Caenorhabditis elegans
Creators Name:Nehammer, C., Podolska, A., Mackowiak, S.D., Kagias, K. and Pocock, R.
Abstract:The ability of animals to sense and respond to elevated temperature is essential for survival. Transcriptional control of the heat stress response has been much studied, whereas its posttranscriptional regulation by microRNAs (miRNAs) is not well understood. Here we analyzed the miRNA response to heat stress in Caenorhabditis elegans and show that a discrete subset of miRNAs is thermoregulated. Using in-depth phenotypic analyses of miRNA deletion mutant strains we reveal multiple developmental and post-developmental survival and behavioral functions for specific miRNAs during heat stress. We have identified additional functions for already known players (mir-71 and mir-239) as well as identifying mir-80 and the mir-229 mir-64-66 cluster as important regulators of the heat stress response in C. elegans. These findings uncover an additional layer of complexity to the regulation of stress signaling that enables animals to robustly respond to the changing environment.
Keywords:Caenorhabditis elegans Proteins, Gene Expression Regulation, Heat-Shock Response, MicroRNAs, Transcriptional Activation, Animals, Caenorhabditis elegans
Source:Scientific Reports
ISSN:2045-2322
Publisher:Nature Publishing Group
Volume:5
Page Range:8866
Date:9 March 2015
Additional Information:Erratum in: Sci Rep 9(1): 7619
Official Publication:https://doi.org/10.1038/srep08866
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library