Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Glucagonoma-induced acute heart failure

[thumbnail of 14519oa.pdf] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
98kB

Item Type:Article
Title:Glucagonoma-induced acute heart failure
Creators Name:Zhang, K., Lehner, L.J., Praeger, D., Baumann, G., Knebel, F., Quinkler, M. and Roepke, T.K.
Abstract:Neuroendocrine tumours (NETs) represent a broad spectrum of tumours, of which the serotonin-producing carcinoid is the most common and has been shown to cause right ventricular heart failure. However, an association between heart failure and NETs other than carcinoid has not been established so far. In this case report, we describe a 51-year-old patient with a glucagon-producing NET of the pancreas who developed acute heart failure and even cardiogenic shock despite therapy. Heart failure eventually regressed after initialising i.v. treatment with the somatostatin analogue octreotide. Chromogranin A as a tumour marker was shown to be significantly elevated, and it decreased with clinical improvement of the patient. The effects of long-time stimulation of glucagon on the myocardium have not been studied yet; however, sarcoplasmic reticulum calcium leak can be discussed as a possible mechanism for glucagon-induced heart failure.
Source:Endocrinology Diabetes and Metabolism Case Reports
ISSN:2052-0573
Publisher:BioScientifica
Volume:2014
Page Range:140061
Date:2014
Official Publication:https://doi.org/10.1530/EDM-14-0061
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library