Rsp5/Nedd4 clears cells of heat-damaged proteins

Tools

PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
161kB

Item Type:	Editorial
Title:	Rsp5/Nedd4 clears cells of heat-damaged proteins
Creators Name:	Sommer, T., Weber, A. and Jarosch, E.
Abstract:	Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat.
Keywords:	Endosomal Sorting Complexes Required for Transport, HSP40 Heat-Shock Proteins, Heat-Shock Response, Protein Folding, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases, Animals
Source:	Nature Cell Biology
ISSN:	1465-7392
Publisher:	Nature Publishing Group
Volume:	16
Number:	12
Page Range:	1130-1132
Date:	1 December 2014
Official Publication:	https://doi.org/10.1038/ncb3079
PubMed:	View item in PubMed

Repository Staff Only: item control page

Download Statistics

Downloads

Downloads per month over past year