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Rsp5/Nedd4 clears cells of heat-damaged proteins

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Item Type:Editorial
Title:Rsp5/Nedd4 clears cells of heat-damaged proteins
Creators Name:Sommer, T., Weber, A. and Jarosch, E.
Abstract:Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat.
Keywords:Endosomal Sorting Complexes Required for Transport, HSP40 Heat-Shock Proteins, Heat-Shock Response, Protein Folding, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases, Animals
Source:Nature Cell Biology
ISSN:1465-7392
Publisher:Nature Publishing Group
Volume:16
Number:12
Page Range:1130-1132
Date:1 December 2014
Official Publication:https://doi.org/10.1038/ncb3079
PubMed:View item in PubMed

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