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| Item Type: | Article |
|---|---|
| Title: | Drep-2 is a novel synaptic protein important for learning and memory |
| Creators Name: | Andlauer, T.F.M., Scholz-Kornehl, S., Tian, R., Kirchner, M., Babikir, H.A., Depner, H., Loll, B., Quentin, C., Gupta, V.K., Holt, M.G., Dipt, S., Cressy, M., Wahl, M.C., Fiala, A., Selbach, M., Schwärzel, M. and Sigrist, S.J. |
| Abstract: | CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short- and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation. |
| Keywords: | CIDE-N Protein Family, Fragile X Syndrome, Learning and Memory, Metabotropic Glutamate Receptors, Mushroom Body, Neuroscience, Synapses, Animals, Drosophila melanogaster |
| Source: | eLife |
| ISSN: | 2050-084X |
| Publisher: | eLife Sciences Publications |
| Volume: | 3 |
| Page Range: | e03895 |
| Date: | 13 November 2014 |
| Official Publication: | https://doi.org/10.7554/eLife.03895 |
| PubMed: | View item in PubMed |
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