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The investigation of acute optic neuritis: a review and proposed protocol

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Item Type:Review
Title:The investigation of acute optic neuritis: a review and proposed protocol
Creators Name:Petzold, A., Wattjes, M.P., Costello, F., Flores-Rivera, J., Fraser, C.L., Fujihara, K., Leavitt, J., Marignier, R., Paul, F., Schippling, S., Sindic, C., Villoslada, P., Weinshenker, B. and Plant, G.T.
Abstract:Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.
Keywords:Magnetic Resonance Imaging, Medical History Taking, Optic Neuritis, Optical Coherence Tomography, Practice Guidelines as Topic
Source:Nature Reviews Neurology
Publisher:Nature Publishing Group
Page Range:447-458
Date:August 2014
Additional Information:Erratum in: Nat Rev Neurol 10(8): i.
Official Publication:https://doi.org/10.1038/nrneurol.2014.108
PubMed:View item in PubMed

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