MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth

Tools

Item Type:	Article
Title:	MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth
Creators Name:	Domeniconi, M., Zampieri, N., Spencer, T., Hilaire, M., Mellado, W., Chao, M.V. and Filbin, M.T.
Abstract:	The three known inhibitors of axonal regeneration present in myelin-MAG, Nogo, and OMgp-all interact with the same receptor complex to effect inhibition via protein kinase C (PKC)-dependent activation of the small GTPase Rho. The transducing component of this receptor complex is the p75 neurotrophin receptor. Here we show that MAG binding to cerebellar neurons induces alpha- and then gamma-secretase proteolytic cleavage of p75, in a protein kinase C-dependent manner, and that this cleavage is necessary for both activation of Rho and inhibition of neurite outgrowth.
Keywords:	Amyloid Precursor Protein Secretases, Aspartic Acid Endopeptidases, Cerebellum, Cultured Cells, Drug Interactions, Endopeptidases, Enzyme Activation, Enzyme Inhibitors, Membrane Proteins, Myelin-Associated Glycoprotein, Nerve Growth Factor Receptor, Nerve Growth Factor Receptors , Neural Inhibition, Neurites, Neuroblastoma, Neurons, Recombinant Fusion Proteins, rho GTP-Binding Proteins, Tertiary OligopeptidesProtein Structure, Tetradecanoylphorbol Acetate, Transfection, Western Blotting, Animals, Cricetinae, Cricetulus, Rats
Source:	Neuron
ISSN:	0896-6273
Publisher:	Cell Press
Volume:	46
Number:	6
Page Range:	849-855
Date:	16 June 2005
Official Publication:	https://doi.org/10.1016/j.neuron.2005.05.029
PubMed:	View item in PubMed

Repository Staff Only: item control page