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Polymerization, bending, tension: What happens at the leading edge of motile cells?

Item Type:Article
Title:Polymerization, bending, tension: What happens at the leading edge of motile cells?
Creators Name:Falcke, M. and Zimmermann, J.
Abstract:The forces experienced by filaments in actin based propulsion in reconstituted systems and cell motility, the mechanical properties of the lamellipodium of motile cells due to filament branching and cross-linking, the free filament contour length between branch points, the mechanisms of the force-velocity relation and velocity oscillations are all topics of ongoing debate. Here, we review results with a modelling concept considering the F-actin network as weakly cross-linked in a region with dynamic depth close to the propelled obstacle and gel-like further back. It offers quantitative explanations for steady motion and oscillation mechanisms in reconstituted systems and motile cells, and the force-velocity relation of fish keratocytes.
Keywords:Branched Actin Networks, Force-Velocity Relation, Retrograde Flow, Migrating Cells, Arp2/3 Complex, Cross-Linking, Lamellipodial Protrusion, Cytoskeletal Dynamics, Electron Tomography, Lipid Vesicles
Source:European Physical Journal - Special Topics
Page Range:1353-1372
Date:June 2014
Additional Information:Authors' reply in: Eur Phys J Spec Top 223(7): 1433-1435.
Official Publication:https://doi.org/10.1140/epjst/e2014-02195-9

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