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Models of chromosome structure

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Item Type:Article
Title:Models of chromosome structure
Creators Name:Nicodemi, M. and Pombo, A.
Abstract:Understanding the mechanisms that control chromosome folding in the nucleus of eukaryotes and their contribution to gene regulation is a key open issue in molecular biology. Microscopy and chromatin-capture techniques have shown that chromatin has a complex organization, which dynamically changes across organisms and cell types. The need to make sense of such a fascinating complexity has prompted the development of quantitative models from physics, to find the principles of chromosome folding, its origin and function. Here, we concisely review recent advances in chromosome modeling, focusing on a recently proposed framework, the Strings & Binders Switch (SBS) model, which recapitulates key features of chromosome organization in space and time.
Keywords:Cell Nucleus, Chromosome Structures, Chromosomes, Molecular Models, Polymers, Animals
Source:Current Opinion in Cell Biology
Publisher:Elsevier / Current Biology
Page Range:90-95
Date:1 June 2014
Official Publication:https://doi.org/10.1016/j.ceb.2014.04.004
PubMed:View item in PubMed

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