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| Item Type: | Article |
|---|---|
| Title: | Regulation of aldosterone biosynthesis by adrenal renin is mediated through AT1 receptors in renin transgenic rats |
| Creators Name: | Volpe, M., Rubattu, S., Gigante, G., Ganten, D., Porcellini, A., Russo, R., Romano, M., Enea, I., Lee, M.A. and Trimarco, B. |
| Abstract: | The transgenic (TG) rat (mREN2)27 is characterized by overexpression of the additional mouse Ren-2d gene in the adrenal cortex with marked suppression of renal renin. We have previously shown that in salt-depleted TG rats enhanced activation of mineralocorticoid biosynthesis is associated with selective stimulation of adrenal renin. To investigate whether the local renin-angiotensin system regulates aldosterone biosynthesis in the adrenal cortex of TG rats, we studied the effects of the AT1-angiotensin subtype receptor antagonist DuP 753 on aldosterone production in 5-week-old TG rats during salt restriction. All the rats (n = 56) were shifted from regular chow to a diet containing only 0.04% NaCl for 1 week. The AT1-receptor antagonist DuP 753 (10 mg/kg per day in drinking water) was administered to 27 of these rats during low-salt diet. Subgroups of rats were killed at 0,4, and 7 days. Low-salt diet increased both adrenal renin activity (from 31 +/- 3 to 77 +/- 4 and 85 +/- 2 ng angiotensin I.h-1.mg protein-1 at 4 and 7 days, respectively; P < .001) and mRNA (by 68.4 +/- 10% and 80 +/- 17% from baseline, P < .05). |
| Keywords: | Aldosterone, Angiotensin, Losartan, Renin, Transgenic Rats, Animals, Mice, Rats |
| Source: | Circulation Research |
| ISSN: | 0009-7330 |
| Publisher: | American Heart Association |
| Volume: | 77 |
| Number: | 1 |
| Page Range: | 73-79 |
| Date: | July 1995 |
| Official Publication: | http://circres.ahajournals.org/cgi/content/abstract/77/1/73 |
| PubMed: | View item in PubMed |
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