Possible allelic association of a tyrosine hydroxylase polymorphism with vulnerability to alcohol-withdrawal delirium

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Item Type:	Article
Title:	Possible allelic association of a tyrosine hydroxylase polymorphism with vulnerability to alcohol-withdrawal delirium
Creators Name:	Sander, T., Harms, H., Rommelspacher, H., Hoehe, M. and Schmidt, L.G.
Abstract:	Recently, an association has been reported between schizophrenia and a rare allele containing 10-repeats (A10) of a polymorphic tetranucleotide motif in the first intron of the tyrosine hydroxylase (TH) gene. The present association analysis tested the hypothesis that the A10 candidate allele confers vulnerability to alcohol-withdrawal delirium with visual hallucinations. The genotype of the TH tetranucleotide polymorphism was assessed in 204 German controls and 311 German alcohol-dependent subjects, including 63 alcoholics with a history of visual hallucinations during withdrawal delirium. The frequency of the A10 allele was significantly increased in the alcoholics with withdrawal delirium (3.2%) compared with that in the controls (0.5%; Fisher's exact test: P = 0.03, two-tailed; OR (A10+) = 6.85, 95% confidence interval: 1.52-30.79). The possible allelic association suggests that allelic variation at the TH locus mediates vulnerability to alcohol-withdrawal delirium in a small proportion of alcohol-dependent subjects.
Keywords:	Tyrosine Hydroxylase Gene, Association Study, Candidate Gene, Alcohol Dependenc, Delirium
Source:	Psychiatric Genetics
ISSN:	0955-8829
Volume:	8
Number:	1
Page Range:	13-17
Date:	1998
Official Publication:	http://pt.wkhealth.com/pt/re/lwwgateway/landingpage.htm;jsessionid=X6NWmPRfslbHZ6bgwxtJcm3TmmGj17pQp01LJ14G41mQyLWPL7m4!1722561905!181195628!8091!-1?sid=WKPTLP:landingpage&an=00041444-199800810-00002
PubMed:	View item in PubMed

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