The patent situation concerning the treatment of diseases associated with autoantibodies directed against G-protein-coupled receptors

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Item Type:	Review
Title:	The patent situation concerning the treatment of diseases associated with autoantibodies directed against G-protein-coupled receptors
Creators Name:	Haberland, A., Wallukat, G. and Schimke, I.
Abstract:	Agonist-like autoantibodies against receptors of the G-protein-coupled signal cascade have been identified as the pathogenic principle for a variety of diseases, especially those of the heart and vascular system. Consequently, the elimination or neutralization of such autoantibodies is an advised goal for causal therapeutic intervention. This article provides a short, noncomplete overview about remarkable developmental strategies and technical solutions for the therapy of diseases, associated with G-protein-coupled receptor autoantibodies. According to the immunoglobulin nature of the therapeutic target, several strategies are possible, such as the use of the autoantibody epitope sequences as competitors or binding molecules for specific autoantibody-elimination by apheresis. Complete immunoglobulin elimination, as is currently being tested in autoantibody-positive cardiomyopathy patients, would be a nonspecific solution as would the use of immunosuppressant agents. The use of autoantibody-binding molecules on an aptamer basis for neutralization or elimination is a newly developed specific therapeutic option.
Keywords:	Autoantibodies, Cardiomyopathies, G-Protein-Coupled Receptors, Immunosuppressive Agents, Nucleotide Aptamers, Patents as Topic, Animals
Source:	Pharmaceutical Patent Analyst
ISSN:	2046-8954
Publisher:	Future Science
Volume:	2
Number:	2
Page Range:	231-248
Date:	March 2013
Official Publication:	https://doi.org/10.4155/ppa.12.88
PubMed:	View item in PubMed

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