Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice

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Item Type:	Article
Title:	Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice
Creators Name:	Yasuda, T., Wirtz, T., Zhang, B., Wunderlich, T., Schmidt-Supprian, M., Sommermann, T. and Rajewsky, K.
Abstract:	Epstein-Barr virus (EBV) is a γ herpes virus endemic in humans and transforming human B lymphocytes. It causes a variety of human pathologies ranging from infectious mononucleosis upon acute infection to EBV-driven B-cell lymphomas. In humans, EBV-infected cells are under powerful immune surveillance by T and NK cells. If this immune surveillance is compromised as in immunosuppressed (AIDS- or posttransplantation) patients, the virus can spread from rare, EBV-containing cells and cause life-threatening pathologies. We have found that EBV immune surveillance and lymphomagenesis can be modeled in mice by targeted expression of key EBV proteins in the B-cell lineage. As EBV does not infect mouse B cells and mice have thus not coevolved with the virus, EBV exploits basic modes of the host immune response to optimize its coexistence with the host.
Keywords:	Acute Disease, Animal Disease Models, B-Cell Lymphoma, B-Lymphocytes, Epstein-Barr Virus Infections, Immunologic Surveillance, Immunosuppression, Signal Transduction, T-Lymphocytes, Viral Matrix Proteins, Animals, Mice
Source:	Cold Spring Harbor Symposia on Quantitative Biology
ISSN:	0091-7451
Publisher:	Cold Spring Harbor Laboratory Press
Volume:	78
Page Range:	259-263
Date:	15 November 2013
Official Publication:	https://doi.org/10.1101/sqb.2013.78.020222
PubMed:	View item in PubMed

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