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| Item Type: | Article |
|---|---|
| Title: | Serum metabolites related to cardiorespiratory fitness, physical activity energy expenditure, sedentary time and vigorous activity |
| Creators Name: | Wientzek, A., Floegel, A., Knüppel, S., Vigl, M., Drogan, D., Adamski, J., Pischon, T. and Boeing, H. |
| Abstract: | The aim of our study was to investigate the relationship between objectively measured physical activity (PA) and cardiorespiratory fitness (CRF) and serum metabolites measured by targeted metabolomics in a population-based study. A total of 100 subjects provided 2 fasting blood samples and engaged in a CRF and PA measurement at 2 visits 4 months apart. CRF was estimated from a step test, whereas physical activity energy expenditure (PAEE), time spent sedentary and time spend in vigorous activity were measured by a combined heart rate and movement sensor for a total of 8 days. Serum metabolite concentrations were determined by flow injection analysis tandem mass spectrometry (FIA-MS/MS). Linear mixed models were applied with multivariable adjustment and p-values were corrected for multiple testing. Furthermore, we explored the associations between CRF, PA and two metabolite factors that have previously been linked to risk of type 2 diabetes. CRF was associated with two phosphatidylcholine clusters independently of all other exposures. Lysophosphatidylcholine C14:0 and methionine were significantly negatively associated with PAEE and sedentary time. CRF was positively associated with the type 2 diabetes protective factor. Vigorous activity was positively associated with the type 2 diabetes risk factor in the mutually adjusted model. Our results suggest that CRF and PA are associated with serum metabolites, especially CRF with phosphatidylcholines and with the type 2 diabetes protective factor. PAEE and sedentary time were associated with methionine. The identified metabolites could be potential mediators of the protective effects of CRF and PA on chronic disease risk. |
| Keywords: | Physical Activity, Physical Fitness, Methionine, Phosphatidylcholines |
| Source: | International Journal of Sport Nutrition and Exercise Metabolism |
| ISSN: | 1526-484X |
| Publisher: | Human Kinetics Publishers |
| Volume: | 24 |
| Number: | 2 |
| Page Range: | 215-226 |
| Date: | April 2014 |
| Official Publication: | https://doi.org/10.1123/ijsnem.2013-0048 |
| PubMed: | View item in PubMed |
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