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Pathogenese und Diagnostik von AA-Amyloidosen [Pathogenesis and diagnostics of AA amyloidosis]

Item Type:Review
Title:Pathogenese und Diagnostik von AA-Amyloidosen [Pathogenesis and diagnostics of AA amyloidosis]
Creators Name:Elitok, S. and Kettritz, R.
Abstract:AA amyloidosis is associated with high morbidity and mortality. Underlying diseases consist of chronic inflammatory conditions, and rheumatoid disorders are the leading causes in Europe. Generation of AA amyloid is a consequence of sustained production of the acute-phase protein serum amyloid A (SAA). This physiologic protein undergoes misfolding and aggregation, promoting formation of a complex with serum amyloid P (SAP). Other components of this complex include different glycosaminoglycan forms. These rather insoluble fibrils disrupt tissue structures and, moreover, interact with different cell types. Renal disease manifestation consists of proteinuria, frequently in the nephrotic range. When this condition is suspected clinically, Congo red staining of affected tissues followed by microscopy using polarized light and immunohistochemical staining for SAA are required to univocally establish the diagnosis of AA amyloidosis.myloid A.
Keywords:AA Amyloidosis, Serum Amyloid A, Serum Amyloid P, Rheumatoid Disorders, Nephrotic Syndrome
Page Range:285-290
Date:July 2008
Official Publication:https://doi.org/10.1007/s11560-008-0170-y

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