The role of IP(3)R clustering in Ca(2+) signalinG

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Item Type:	Article
Title:	The role of IP(3)R clustering in Ca(2+) signalinG
Creators Name:	Skupin, A. and Falcke, M.
Abstract:	Ca(2+) is the most important second messenger controlling a variety of intracellular processes by oscillations of the cytosolic Ca(2+) concentration. These oscillations occur by Ca(2+) release from the endoplasmic reticulum (ER) into the cytosol through channels and the re-uptake of Ca(2+) into the ER by pumps. A common channel type present in many cell types is the inositol trisphosphate receptor (IP(3)R), which is activated by IP(3) and Ca(2+) itself leading to Ca(2+) induced Ca(2+) release (CICR). We have shown in an experimental study, that Ca(2+) oscillations are sequences of random spikes that occur by wave nucleation. We use here our recently developed model for Ca(2+) dynamics in 3 dimension to illuminate the role of IP(3)R clustering within spatial extended systems.
Keywords:	Cell Signaling, Calcium Oscillations, Modeling, Clustering, Animals
Source:	Genome Informatics
Series Name:	Genome Informatics
Title of Book:	Genome Informatics 2008
ISSN:	0919-9454
ISBN:	978-1-84816-299-0
Publisher:	J-Stage
Volume:	20
Page Range:	15-24
Date:	June 2008
Official Publication:	https://doi.org/10.1142/9781848163003_0002
PubMed:	View item in PubMed

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