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Polymer physics, scaling and heterogeneity in the spatial organisation of chromosomes in the cell nucleus

Item Type:Review
Title:Polymer physics, scaling and heterogeneity in the spatial organisation of chromosomes in the cell nucleus
Creators Name:Barbieri, M., Scialdone, A., Gamba, A., Pombo, A. and Nicodemi, M.
Abstract:We review some of the recent progresses made by the application of polymer physics to the understanding of the spatial organization of chromosomes in the cell nucleus. In particular, we focus on some scaling properties of the contact probability of pairs of sites, discovered by recent genome-wide experiments exploiting new technologies such as Hi-C methods.
Source:Soft Matter
ISSN:1744-683X
Publisher:Royal Society of Chemistry
Volume:9
Number:36
Page Range:8631-8635
Date:28 September 2013
Official Publication:https://doi.org/10.1039/C3SM51436F

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