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Retigabine strongly reduces repetitive firing in rat entorhinal cortex

Item Type:Article
Title:Retigabine strongly reduces repetitive firing in rat entorhinal cortex
Creators Name:Hetka, R., Rundfeldt, C., Heinemann, U. and Schmitz, D.
Abstract:Retigabine (D-23129) [N-(2-amino-4-(4-fluorobenzylamino)phenyl) carbamic acid ethyl ester] is a novel antiepileptic drug. The compound was shown to possess anticonvulsant properties both in vivo and in vitro. We investigated the effects of retigabine on neurones in the rat medial entorhinal cortex using conventional intracellular recordings in combined hippocampal-entorhinal cortex slices. Retigabine strongly reduced the number of action potentials elicited by 1 s long depolarising current injections. Both the amplitudes of monosynaptic inhibitory postsynaptic potentials/currents (IPSP/Cs) and the amplitudes of excitatory postsynaptic potentials (EPSPs) remained unaffected. The drug increased outward rectification and induced a membrane-potential hyperpolarisation in most of the tested neurones. The findings suggest that retigabine exerts its anticonvulsant effects by activation of a K(+)conductance, however it cannot be excluded from our experiments that other mechanisms may be involved in the effect of retigabine on membrane properties.
Keywords:Retigabine, Anticonvulsant, Entorhinal Cortex, Spike Frequency Habituation, EPSP (Excitatory Postsynaptic Potential), IPSP (Inhibitory Postsynaptic Potential), K+Channel Opener, Animals, Rats
Source:European Journal of Pharmacology
Page Range:165-171
Date:15 December 1999
Official Publication:https://doi.org/10.1016/S0014-2999(99)00786-4
PubMed:View item in PubMed

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