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Characterization of the inhibitory glycine receptor on entorhinal cortex neurons

Item Type:Article
Title:Characterization of the inhibitory glycine receptor on entorhinal cortex neurons
Creators Name:Breustedt, J., Schmitz, D., Heinemann, U. and Schmieden, V.
Abstract:In addition to the well-established functional description of the glycine receptor (GlyR) in the spinal cord, GlyR expression has recently been found in higher brain regions, such as the striatum or hippocampus. In this study we have investigated the electrophysiological response of glycine in the rat entorhinal cortex slice. In all recorded cells we found significant current responses to glycine with an EC(50) value of about 100 micro m. Most importantly, we detected a cross-inhibition of glycine responses by GABA but not vice versa. These findings are in line with recent published data of cross-talks between GABA(A)R and GlyR but indicate a novel type of cross-inhibition of these receptors in the entorhinal cortex.
Keywords:Cross-Inhibition, Gaba Receptor, Glycine Receptor, Strychnine, Animals, Rats
Source:European Journal of Neuroscience
Publisher:Blackwell Publishing
Page Range:1987-1991
Date:April 2004
Official Publication:https://doi.org/10.1111/j.1460-9568.2004.03266.x
PubMed:View item in PubMed

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