Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories

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Item Type:	Article
Title:	Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories
Creators Name:	Plath, N., Ohana, O., Dammermann, B., Errington, M.L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., Kobalz, U., Stawrakakis, A., Fernandez, E., Waltereit, R., Bick-Sander, A., Therstappen, E., Cooke, S.F., Blanquet, V., Wurst, W., Salmen, B., Boesl, M.R., Lipp, H.P., Grant, S.G.N., Bliss, T.V.P., Wolfer, D.P. and Kuhl, D.
Abstract:	Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.
Keywords:	Sysneuro, Signaling, Proteins, Animals, Mice
Source:	Neuron
ISSN:	0896-6273
Publisher:	Cell Press
Volume:	52
Number:	3
Page Range:	437-444
Date:	9 November 2006
Official Publication:	https://doi.org/10.1016/j.neuron.2006.08.024
PubMed:	View item in PubMed

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