Cytogenetic risk grouping by the monosomal karyotype classification is superior in predicting the outcome of acute myeloid leukemia undergoing allogeneic stem cell transplantation in complete remission

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Item Type:	Article
Title:	Cytogenetic risk grouping by the monosomal karyotype classification is superior in predicting the outcome of acute myeloid leukemia undergoing allogeneic stem cell transplantation in complete remission
Creators Name:	Hemmati, P.G., Schulze-Luckow, A., Terwey, T.H., le Coutre, P., Vuong, L.G., Doerken, B. and Arnold, R.
Abstract:	We retrospectively analyzed the impact of cytogenetic abnormalities grouped according to the monosomal karyotype (MK) classification or the Southwest Oncology/Eastern Cooperative Oncology Group (SWOG/ECOG) definition in 263 patients with acute myeloid leukemia (AML) who underwent allogeneic stem cell transplantation (alloSCT) in complete remission (CR) at our center. Risk grouping using to the MK criteria shows a highly significant difference in 5-year overall survival (OS) ranging between 67% the most favorable and 32% for the poorest risk group (p=0.001). Although similar precise in predicting OS, the MK scheme better separates patients with respect to relapse incidence as compared to the SWOG/ECOG grouping (p=0.0001 versus p=0.01). Notably, patients displaying non-MK abnormalities (MK-) had a 5-year relapse incidence identical to those cytogenetically normal (CN), i.e. 24%. Multivariate analysis revealed that the MK classification is an independent prognosticator and superior in predicting OS (HR 3.74, p=0.01) and relapse incidence (HR 3.74, p=0.005) as compared to the SWOG/ECOG criteria. Finally, subgroup analysis revealed that the prognostic capacity of the MK classification is highly significant in patients treated with standard myeloablative conditioning (MAC) prior to alloSCT (p=0.0011 for OS, p=0.0007 for relapse). In contrast, the MK grouping failed to predict OS or relapse incidence in patients treated with reduced intensity conditioning (RIC). Taken together, these results indicate that the MK classification is superior in predicting the overall outcome of patients with AML undergoing alloSCT in CR. Furthermore, our data suggest that the genetic risk profile of MK- and CN patients is mostly overlapping in this setting.
Keywords:	Allogeneic Stem Cell Transplantation, Acute Myeloid Leukemia, Monosomal Karyotype, Reduced Intensity Conditioning
Source:	European Journal of Haematology
ISSN:	0902-4441
Publisher:	Wiley-Blackwell
Volume:	92
Number:	2
Page Range:	102-110
Date:	February 2014
Official Publication:	https://doi.org/10.1111/ejh.12216
PubMed:	View item in PubMed

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