Inhibitory gradient along the dorsoventral axis in the medial entorhinal cortex

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Item Type:	Article
Title:	Inhibitory gradient along the dorsoventral axis in the medial entorhinal cortex
Creators Name:	Beed, P., Gundlfinger, A., Schneiderbauer, S., Song, J., Boehm, C., Burgalossi, A., Brecht, M., Vida, I. and Schmitz, D.
Abstract:	Local inhibitory microcircuits in the medial entorhinal cortex (MEC) and their role in network activity are little investigated. Using a combination of electrophysiological, optical, and morphological circuit analysis tools, we find that layer II stellate cells are embedded in a dense local inhibitory microcircuit. Specifically, we report a gradient of inhibitory inputs along the dorsoventral axis of the MEC, with the majority of this local inhibition arising from parvalbumin positive (PV+) interneurons. Finally, the gradient of PV+ fibers is accompanied by a gradient in the power of extracellular network oscillations in the gamma range, measured both in vitro and in vivo. The reported differences in the inhibitory microcircuitry in layer II of the MEC may therefore have a profound functional impact on the computational working principles at different locations of the entorhinal network and influence the input pathways to the hippocampus.
Keywords:	Action Potentials, Electric Stimulation, Entorhinal Cortex, Evoked Potentials, Glutamic Acid, Inhibitory Postsynaptic Potentials, Interneurons, Lysine, Nerve Net, Neural Inhibition, Nonparametric Statistics, Parvalbumins, Patch-Clamp Techniques, Peptides, Vesicular Inhibitory Amino Acid Transport Proteins, Animals, Rats
Source:	Neuron
ISSN:	0896-6273
Publisher:	Cell Press
Volume:	79
Number:	6
Page Range:	1197-1207
Date:	18 September 2013
Official Publication:	https://doi.org/10.1016/j.neuron.2013.06.038
PubMed:	View item in PubMed

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