3D chromatin regulation of Sonic hedgehog in the limb buds

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Item Type:	Editorial
Title:	3D chromatin regulation of Sonic hedgehog in the limb buds
Creators Name:	Ferrai, C. and Pombo, A.
Abstract:	Understanding the mechanisms that regulate gene expression during development is a major challenge in science. In this issue of Developmental Cell, Amano and colleagues report that expression of Sonic hedgehog (Shh) protein in the posterior mesenchyme of the mouse limb bud correlates with a long-range chromatin interaction with enhancer MFCS1 and looping of the Shh locus from its chromosome territory (CT).
Keywords:	Chromatin, Developmental Gene Expression Regulation, Genetic Enhancer Elements, Hedgehog Proteins, Limb Buds, Mesoderm, Morphogenesis, Animals, Mice
Source:	Developmental Cell
ISSN:	1534-5807
Publisher:	Cell Press
Volume:	16
Number:	1
Page Range:	9-11
Date:	20 January 2009
Official Publication:	https://doi.org/10.1016/j.devcel.2008.12.010
PubMed:	View item in PubMed

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