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| Item Type: | Article |
|---|---|
| Title: | Impaired synaptic plasticity in the surround of perinatally acquired dysplasia in rat cerebral cortex |
| Creators Name: | Peters, O., Redecker, C., Hagemann, G., Bruehl, C., Luhmann, H.J. and Witte, O.W. |
| Abstract: | Freeze-lesion induced neocortical dysplasias in rats mimic numerous aspects of human polymicrogyria and are used as a model for the study of developmental migration disorders. Since memory tests have demonstrated learning deficits in rodents with neocortical malformations, we investigated the expression and properties of long-term potentiation (LTP) in neocortical slices from adult freeze-lesioned and control rats. Field potentials, recorded in layer II/III at a distance of 2-3 mm lateral to perinatally induced microgyri, were strongly enhanced following theta-burst stimulation in layer VI (amplitude: 174 +/- 4%) compared to controls (110 +/- 2%). In contrast, in layer IV of the freeze-lesioned cortex LTP could not reliably be induced. Histochemical analysis, performed to elucidate the cellular basis of the impaired plasticity, revealed diminished amounts of the GABAA-receptor subunit gamma2 in the paramicrogyral zone, likely representing a diminished GABA-ergic filter, which is thought to prevent LTP induced in layer VI under normal conditions. Cytochrome-oxidase staining after electrophysiological examination disclosed that LTP in layer IV of the freeze-lesioned cortex could only be elicited, when stimulation was applied within a preserved barrel cortex. Our study provides evidence that focal cryolesions during cortical development cause an impaired synaptic plasticity that may underlie learning disabilities. |
| Keywords: | Developmental Migration Disorder, Learning Disabilities, Long-Term Potentiation, Neocortical Malformation, Polymicrogyria, Animals, Rats, Wistar Rats |
| Source: | Cerebral Cortex |
| ISSN: | 1047-3211 |
| Publisher: | Oxford University Press |
| Volume: | 14 |
| Number: | 10 |
| Page Range: | 1081-1087 |
| Date: | October 2004 |
| Official Publication: | https://doi.org/10.1093/cercor/bhh067 |
| PubMed: | View item in PubMed |
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