Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits

Tools

PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB

Item Type:	Article
Title:	Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits
Creators Name:	Megraw, M., Mukherjee, S. and Ohler, U.
Abstract:	WaRSwap is a randomization algorithm that for the first time provides a practical network motif discovery method for large multi-layer networks, for example those that include transcription factors, microRNAs, and non-regulatory protein coding genes. The algorithm is applicable to systems with tens of thousands of genes, while accounting for critical aspects of biological networks, including self-loops, large hubs, and target rearrangements. We validate WaRSwap on a newly inferred regulatory network from Arabidopsis thaliana, and compare outcomes on published Drosophila and human networks. Specifically, sustained input switches are among the few over-represented circuits across this diverse set of eukaryotes.
Keywords:	Gene Regulation, microRNA, Network Motif, Transcription Factor, Animals, Drosophila Melanogaster
Source:	Genome Biology
ISSN:	1465-6906
Publisher:	BioMed Central
Volume:	14
Number:	8
Page Range:	R85
Date:	23 August 2013
Official Publication:	https://doi.org/10.1186/gb-2013-14-8-r85
PubMed:	View item in PubMed

Repository Staff Only: item control page

Download Statistics

Downloads

Downloads per month over past year