![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
| Item Type: | Article |
|---|---|
| Title: | Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis |
| Creators Name: | Roth, N.M., Saidha, S., Zimmermann, H., Brandt, A.U., Oberwahrenbrock, T., Maragakis, N.J., Tumani, H., Ludolph, A.C., Meyer, T., Calabresi, P.A. and Paul, F. |
| Abstract: | BACKGROUND AND PURPOSE: In recent years a possible non-motor involvement of the nervous system in amyotrophic lateral sclerosis (ALS) has come into the focus of research and has been investigated by numerous techniques. Optical coherence tomography (OCT) - with its potential to reveal neuroaxonal retinal damage - may be an appropriate tool to investigate whether the anterior visual pathway is involved. Our aim was to determine whether OCT-based measures of retinal nerve fiber layer, ganglion cell layer, inner nuclear layer and outer nuclear layer thickness are abnormal in ALS, or correlated with disease severity. METHODS: Seventy-six ALS patients (144 eyes) and 54 healthy controls (108 eyes; HCs) were examined with OCT, including automated intraretinal macular segmentation. ALS disease severity was determined with the Amyotrophic Lateral Sclerosis Functional Rating Scale - Revised. RESULTS: There was no significant difference between ALS patients and HCs in any of the examined OCT measures. Moreover, OCT parameters showed no correlation with clinical measures of disease severity. CONCLUSIONS: These findings indicate that involvement of the anterior visual pathway is not one of the non-motor manifestations of ALS. |
| Keywords: | Amyotrophic Lateral Sclerosis, Multisystem Disorder, Optical Coherence Tomography, Retina |
| Source: | European Journal of Neurology |
| ISSN: | 1351-5101 |
| Publisher: | Wiley-Blackwell |
| Volume: | 20 |
| Number: | 8 |
| Page Range: | 1170-1176 |
| Date: | August 2013 |
| Official Publication: | https://doi.org/10.1111/ene.12146 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
